Mazdutide 10mg

Buy Mazdutide: Research-Grade Peptide for Metabolic Research

Metabolic research has made great strides with the development of advanced peptide compounds that provide valuable insights into glucose metabolism and energy regulation. Scientists looking to buy mazdutide for lab research can now get this dual agonist from specialized suppliers like Loti Labs where quality standards are strict for consistent results.

Mazdutide is a breakthrough in peptide research, a synthetic peptide analog of the gut hormone oxyntomodulin. This compound has gained attention in lab research due to its unique dual receptor targeting mechanism, making it a must have for researchers studying metabolic disorders and glucose dependent insulin secretion pathways.

Molecular Structure of Mazdutide

Mazdutide is a 33 amino acid synthetic peptide with specific modifications for research use. The molecular formula C225H348N48O68 corresponds to a molecular weight of approximately 4813 g/mol but may vary slightly depending on the salt form and peptide configuration used in manufacturing.

A key structural feature of this compound is the C20 fatty diacid moiety attached to the lysine residue at position 20. This modification is a hydrophilic linker that allows strong albumin binding in plasma, extending the half life of the compound in experimental systems. Research shows that mazdutide is highly bound to albumin which prolongs the activity and allows for longer experimental protocols.

The compound is a solid white to off white lyophilized powder optimized for shipping and long term storage. Loti Labs maintains high purity standards, current stock is 99.74% pure as verified by analytical testing.

Specifications:

• Amino Acid Sequence: His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2* Purity: 99%+
• Alternative Names: IBI-362, LY3305677
• Physical Form: Lyophilized powder
• CAS number: 2259884-03-0

Mechanism of Action in Research

Mazdutide is a dual agonist that targets both glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R). Research shows that mazdutide binds human GCGR with a Ki of 17.7 nM and human GLP-1R with Ki of 28.6 nM, strong receptor binding for both targets.

In mouse islet studies, the compound stimulates insulin secretion with an EC50 of 5.2 nM, a powerful tool for glucose metabolism research. The dual agonist activity allows researchers to study the complex interplay between glucagon like peptide signaling and glucagon receptor activation in controlled conditions.

Research shows this dual targeting approach offers multiple ways to study energy expenditure and fat metabolism. The compound acts on both human and mouse GCGR making it useful for cross species studies and GLP-1R activity allows for glucose dependent insulin secretion mechanism studies.

Mazdutide potently activates both receptor pathways, designed for energy expenditure research in animal models. This dual functionality gives researchers insight into how these signaling pathways interact to regulate body weight and metabolic homeostasis.

Research and Lab Use

Lab research use of this compound covers multiple areas of metabolic research. Primary research applications include:

Metabolic Disorder Research:

• Glucose metabolism pathway research
• Energy expenditure studies in animal models
• Fat metabolism studies in diabetic mice
• Body weight research

Experimental Protocols: Research teams have used this compound in studies of metabolic responses in cell culture and animal models. The long acting nature of the compound makes it ideal for extended experimental protocols where sustained receptor activation is required.

Studies in chinese adults and various animal models have given researchers data on how dual agonist compounds interact with metabolic pathways. The compound reduces body weight in experimental models and affects glucose metabolism making it useful for obesity and diabetes research.Lab Preparation: When using in research, scientists typically prepare stock solutions using sterile technique. The compound should be dissolved, filtered through a 0.22 μm filter and sterilized before use. Use the standard dilution formula C1V1 = C2V2 for animal studies and other experimental applications.

Storage and Handling

Proper storage is crucial for peptide integrity and reproducible research results. Mazdutide should be stored under the following conditions:

Storage Requirements:

• Long-term: -80°C up to 6 months
• Short-term: -20°C up to 1 month
• Protect from moisture and light at all times
• Store in sealed, light-protective vials

Preparation Guidelines: Stock solutions must be prepared using aseptic technique. The peptide should be aliquoted after initial dissolution to avoid repeated freeze-thaw cycles which can compromise compound stability. When prepared correctly researchers can maintain consistent experimental conditions across multiple studies.

Handling protocols require following institutional guidelines for research chemicals. All personnel should review the safety data sheet (SDS) and certificate of analysis (COA) provided with each batch to ensure proper handling procedures are followed.

Why Buy from Loti Labs

Researchers who buy mazdutide from Loti Labs receive full documentation to support their lab research. Each order includes:

Quality Assurance:

• Third-party HPLC testing for 99%+ purity
• Receptor binding affinity testing for dual GLP-1R/GCGR activity
• Complete certificate of analysis (COA) for each batch
• Safety data sheet (SDS) for handling

Documentation Package: Every order includes detailed data sheets, handling instructions and analytical results. This documentation supports lab compliance requirements and allows researchers to keep detailed experimental records.

Specialized Packaging: Products are packaged using specialized methods to preserve peptide integrity during shipping and storage. This attention to packaging details helps to maximize shelf life and ensures researchers receive compounds in optimal condition.

Price and Availability: Check current price and product availability in the online catalog. Multiple variants may be available depending on research requirements and bulk pricing is available for larger research projects.

Research Use Only

All products sold by Loti Labs are for research use only. This means the compound can only be used for in-vitro laboratory testing and experimentation. Human or veterinary use is strictly prohibited under these terms.Mazdutide is not intended for human consumption and should not be misbranded, mislabeled or misused outside of research applications. Researchers must follow institutional protocols for research chemical procurement and use, and all applicable regulations.

Lab personnel should keep records of compound procurement, storage and use to support institutional compliance requirements. Any research involving this compound should be conducted under institutional oversight and approval.

Ordering and Policies

Shipping: Loti Labs ships same day for orders placed before 1pm EST Monday-Friday. Orders placed after 1pm EST or on weekends ship next business day. Researchers can add items to their cart and checkout to select options for their specific needs.

30 Day Satisfaction Guarantee: A 30 day satisfaction guarantee applies to all products. Researchers can return any unopened products for a full refund of the purchase price to support lab budget and reduce procurement risk.

Third-Party Testing: Every batch is tested by third-party HPLC to ensure product purity and accuracy. Additional receptor binding studies confirm dual GLP-1R/GCGR targeting, so researchers can trust their results.

Metabolic Research

Availability of high quality research compounds like mazdutide allows scientists to study complex metabolic pathways and gain new understanding of glucose metabolism, energy expenditure and related physiological processes. As researchers continue to explore dual agonist approaches in the lab, compounds with verified purity and documentation become more important for advancing scientific knowledge.

Research suggests further investigation of these mechanisms may yield valuable insights into metabolic regulation and support the scientific community’s understanding of complex systems. For qualified researchers looking to buy mazdutide for lab use, Loti Labs provides the quality and documentation for rigorous research.

Researchers interested in using this compound in their research protocols can view product specs, request more information and order through established procurement channels. All research should be conducted in accordance with institutional guidelines and under scientific oversight to ensure safety and scientific validity.

References

1. Chen T, et al. The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases. J Med Chem. 2022 Mar 10;65(5):3685-3705. Link
2. Jiang H, et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun. 2022 Jun 24;13(1):3613. Link
3. Chen Y, Mezo A, Coskun T, et al. Novel dual glucagon and glucagon-like peptide-1 receptor agonist LY3305677 improves glucose control, reduces body weight, and increases energy expenditure in mice. Diabetes. 2021;70(Supplement_1). Link
4. Innovent Biologics. Efficacy and safety of Mazdutide on weight loss among diabetic and overweight adults. PubMed Central. 2023. Link
5. Innovent Biologics. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) in Chinese adults with overweight or obesity. PubMed Central. 2023. Link
6. Ji, L., Gao, L., et al. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) in Chinese adults with overweight or obesity. EClinicalMedicine, 54, 101691. Link
7. Innovent Biologics. Innovent announces Phase 2 clinical study of higher dose 9 mg Mazdutide (IBI362) in Chinese adults with obesity achieved the 24-week primary endpoint. PR Newswire. 2023. Link
8. Innovent Biologics. NMPA accepts Innovent’s NDA for Mazdutide. BioSpace. 2023. Link