LGD-4033 10mg/ml (30ml)

Buy LGD4033 Liquid at Loti Labs

Research into selective androgen receptor modulators has come a long way in recent years and LGD-4033 is one of the compounds of interest. As labs around the world are investigating the mechanisms and applications of these selective androgen receptor modulators the demand for high purity research chemicals has grown significantly. For researchers looking to buy LGD-4033 for legitimate scientific research understanding the compound and sourcing requirements becomes crucial.

Scientists and research institutions need reliable access to verified compounds that meet analytical standards. LGD-4033 also known as Ligandrol is a big step forward in SARM research, gives researchers a tool to investigate selective androgen receptor interactions in controlled lab environment.

Molecular Structure of LGD-4033

Chemical Formula: C14H12F6N2O

Molecular Weight: 338.258 g/mol

IUPAC Name: 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoromethylbenzonitrile

CAS #: 1165910-22-4

The molecular structure of LGD-4033 is different from traditional compounds used in research. Originally developed by Ligand Pharmaceuticals, this nonsteroidal oral compound has a pyrrolidine ring system attached to a benzonitrile core with 6 fluorine atoms that contribute to its chemical stability and unique binding properties. Research shows that these structural elements give the compound high affinity for specific receptor targets and selectivity profiles that are very different from anabolic steroids.

Unlike testosterone and other traditional androgens the molecular design of LGD-4033 allows researchers to investigate tissue selective interactions. The compound is synthetic and has specific stereochemistry so researchers can study how structural modifications affect receptor binding and downstream cellular responses.

Mechanism of Action

LGD-4033 is a selective androgen receptor modulator with high affinity for androgen receptors in research settings. Research shows that this compound has an anabolic to androgenic ratio of 10:1 providing researchers a tool to study selective activity in target tissues while minimizing the broader androgenic effects seen with traditional compounds.Research shows that LGD-4033 works through tissue selective agonism at androgen receptors. In lab studies the compound shows high binding activity in muscle and bone tissue preparations and low activity in androgen sensitive tissues like prostate samples. This selectivity is due to the compound’s unique molecular structure which influences gene transcription by recruiting specific co-regulator proteins.

The research mechanism is different from anabolic steroids as LGD-4033 does not get metabolized by CYP19 aromatase or 5α-reductase enzymes in lab studies. This allows researchers to study direct receptor interactions without the confounding effects of metabolite products that complicate steroid research.

Preclinical studies show that LGD-4033 produces anabolic effects at nanomolar concentrations with in vitro efficacy measurements of 132-133% maximum response and EC50 values of 3.6-4.4 nM. These pharmacodynamic properties make the compound useful for dose response studies and mechanistic research.

Research

Clinical trials on LGD-4033 have given the research community some data. Phase 1 trials enrolled 76 healthy young men in double blind, placebo controlled studies for 21 days. Results showed statistically significant, dose dependent increase in lean body mass compared to placebo groups, no serious adverse reactions were reported during the study period.

A subsequent Phase 2 study enrolled 120 older adults recovering from hip fractures and looked at dose ranges from 0.5 mg to 2 mg daily for several weeks. Clinical studies showed significant improvement in muscle mass and strength parameters compared to placebo controls, potential applications for research into muscle wasting conditions and bone health.

Preclinical animal studies show that up to 70% of body mass gained during LGD-4033 administration can be retained after a 4 week recovery period. These retention rates show the compound’s long term effect on muscle tissue in research models and gives insight into the long term effects of selective androgen receptor modulation.

Research suggests LGD-4033 may be useful for muscle atrophy, osteoporosis and related conditions affecting bone density. However researchers note that these clinical studies are preliminary and long term benefits need to be evaluated scientifically before wider research applications can be established.The research shows that unlike testosterone supplementation LGD-4033 treatment in controlled studies does not affect prostate tissue parameters or produce androgenic responses. This selectivity makes the compound very useful for researchers studying muscle growth and bone health without the confounding variables of traditional androgenic compounds.

Storage and Safety

Proper storage protocols are crucial to maintain LGD-4033 research chemical integrity throughout its shelf life. Store LGD-4033 in a cool, dry place away from direct sunlight to preserve product stability and prevent degradation. Under proper environmental conditions the compound will maintain research grade quality for 2-3 years from the manufacturing date.

Laboratory safety protocols require personal protective equipment during handling procedures. Researchers should wear gloves, safety glasses and other protective measures when working with this potent compound. Proper ventilation and standard laboratory safety practices ensure safe handling throughout research applications.

Temperature control is critical for long term storage, refrigeration is recommended for extended storage periods. Avoid exposure to moisture, extreme temperatures or UV light which may compromise the compound’s chemical stability. Research laboratories should implement proper inventory management to track storage duration and environmental conditions.

Safety extends beyond storage to include proper disposal of unused material and contaminated laboratory equipment. Research institutions must follow established protocols for handling and disposing of research chemicals according to institutional and regulatory guidelines.

Why Buy from Loti Labs

Loti Labs offers premium LGD-4033 liquid with verified purity of ≥98%, industry standard for research chemicals. All products come with a Certificate of Analysis from U.S.-based independent laboratories, providing researchers with detailed analytical verification of product composition and purity levels. This documentation supports research reproducibility and regulatory compliance requirements.

Multiple product forms are available to meet specific research needs, powder and liquid forms to enable precise dosing in experimental protocols. The different forms allow researchers to choose the most suitable form for their experimental design and measurement requirements.

Research shows that product purity affects experimental outcomes, verified analytical data is essential for meaningful scientific research. Loti Labs addresses this by having rigorous quality control measures that exceed industry standards for research chemical suppliers.

The company’s commitment to analytical verification gives researchers confidence in their results. Third party testing protocols ensure each batch meets the established purity specifications before distribution to research institutions and laboratories.For fitness enthusiasts and bodybuilders looking to use compounds for personal use, please note that Loti Labs products are for research use only. The company does not support human consumption or athletic performance enhancement outside of legitimate scientific research.

Loti Labs products are for Research Use Only

All products sold by Loti Labs are research chemicals only. This means the use of these compounds is strictly for in-vitro laboratory testing and experimentation. Human use or veterinary applications are strictly forbidden under this classification.

These products are not supplements and may not be misbranded, mislabeled or misused for human consumption. The research use designation ensures compliance with regulatory guidelines while supporting legitimate scientific research into selective androgen receptor modulator mechanisms and applications.

Research purposes include a wide range of legitimate scientific investigations including cellular studies, receptor binding assays, pharmacokinetic evaluations and mechanistic research. However the compounds cannot be used for physical performance enhancement, athletic performance improvement or any applications involving human subjects outside of approved clinical research protocols.

Scientists and research institutions must keep proper documentation of research use compliance. This includes experimental protocols, institutional review board approvals where applicable and proper record keeping of legitimate scientific applications.

The distinction between research chemicals and consumer products is critical for legal compliance and ethical research practices. Researchers must ensure their intended use aligns with research use only designation and institutional guidelines.

Healthcare professionals advising on research projects should be aware that these compounds have not been approved by the FDA for human therapeutic use. Any research involving human subjects requires appropriate regulatory oversight and ethical review processes.

Shipping Policy of Loti Labs

Loti Labs offers same day shipping for orders placed before 1pm EST Monday through Friday, so you get your products fast for time sensitive research. Orders placed after 1pm EST or on weekends are processed and shipped the next business day to maintain our delivery schedule for research institutions.

Free shipping is available on orders over $99, so you can buy in bulk for your research lab and save on procurement costs. This policy supports bulk purchasing for long term research projects and reduces overall cost of procurement.

The expedited shipping recognizes that research timelines often require rapid access to verified compounds. Laboratory schedules and experimental protocols benefit from predictable delivery times to plan and execute your project.

Shipping options accommodate individual researcher needs and institutional procurement requirements. Multiple shipping options so you can choose the delivery method that fits your timeline and budget.Loti Labs offers 30 day satisfaction guarantee on all products purchased from our facility. Simply return any unopened products for a full refund of the purchase price of unused materials so you can shop with confidence.

This guarantee policy recognizes that research requirements can change during project development and provides flexibility for labs managing changing experimental protocols. The satisfaction guarantee allows research institutions to make procurement decisions without financial risk.

Quality assurance through satisfaction guarantees shows the company’s confidence in their analytical verification processes and product quality standards. Researchers benefit from this policy when setting up new experimental protocols or evaluating different supplier options.

The guarantee period allows enough time for researchers to evaluate product quality and suitability for their specific experimental requirements. This timeframe accommodates typical research planning cycles and experimental development phases.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs is tested by a third party using HPLC to ensure product purity and accuracy. This verification process guarantees research grade quality for all LGD-4033 products and gives researchers analytical confidence in their experimental materials.

Independent laboratory verification eliminates potential conflicts of interest in quality assessment and provides objective analytical data for research documentation. Third party testing protocols follow established analytical standards that support research reproducibility and publication requirements.

The HPLC testing method provides precise quantification of active compound concentrations and identifies potential impurities that could affect experimental outcomes. This analytical approach supports high purity standards for meaningful scientific investigation.

Batch specific testing ensures consistent quality across different production runs and allows researchers to track analytical variations that might impact experimental results. Certificate of Analysis documentation provides detailed analytical data for research record keeping and regulatory compliance.

Research institutions benefit from comprehensive analytical verification when setting up experimental protocols and interpreting research outcomes. The availability of detailed analytical data supports peer review processes and publication requirements in scientific journals.

Results showed that independent analytical verification significantly improves research quality and reproducibility compared to supplier self-testing. This commitment to analytical transparency sets Loti Labs apart in the research chemical market.

References

1. Basaria, S., et al. (2013). The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral Selective Androgen Receptor Modulator, in Healthy Young Men. The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, 68(1), 87-95.2. Bhattacharya, I., et al. (2016). Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a Single Dose of LGD-4033. Clinical Pharmacology in Drug Development, 5(6), 513-523.
2. Viking Therapeutics. (2015). Phase 2 Trial of VK5211 in Patients Recovering from Hip Fracture. FierceBiotech.
3. Fragkaki, A., et al. (2018). Human In Vivo Metabolism Study of LGD-4033. Drug Testing and Analysis, 10(11-12), 1635-1645.
4. Australian Government Department of Health. (2020). Therapeutic Goods Administration: Regulation of Selective Androgen Receptor Modulators (SARMs).
5. GlobeNewswire. (2025). Ligandrol LGD-4033 SARMs: Benefits, Results & Alternatives. Retrieved from https://www.globenewswire.com

For researchers looking to buy LGD-4033 for research use only, Loti Labs offers verified research grade compounds with full analytical data. Quality control, third party testing and research use only compliance ensures researchers have access to high purity materials for SARM research.

For more information on LGD-4033 Ligandrol please visit Wikipedia.