Buy Enclomiphene at Loti Labs

Enclomiphene Molecular Structure

Enclomiphene citrate is the trans-isomer of clomiphene citrate, a selective estrogen receptor modulator (SERM) in the triphenylethylene family. This specific stereochemistry is different from its cis-isomer zuclomiphene citrate which has different pharmacological properties.

Chemical Name: (E)-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine citrate

Molecular Formula: C26H28ClNO·C6H8O7

Molecular Weight: 598.08 g/mol

CAS Number: 15690-57-0

PubChem CID: 71398

Structure Classification: Selective estrogen receptor modulator (SERM), trans-isomer of clomiphene citrate

The trans-isomer configuration of enclomiphene is key to its mechanism, as this geometric arrangement is what gives it its antagonistic activity at estrogen receptors. Standard clomiphene citrate has about 62% enclomiphene (trans-isomer) and 38% zuclomiphene (cis-isomer) but pure enclomiphene citrate isolates only the therapeutic component.

Mechanism of Action

Enclomiphene works by blocking estrogen receptors in the hypothalamus and pituitary gland, thus breaking the negative feedback loop that normally suppresses gonadotropin release when estradiol levels rise. This disruption of the negative feedback mechanism in the hypothalamic pituitary gonadal axis triggers a cascade of hormonal responses.

When enclomiphene blocks estrogen receptors at these central regulatory sites, the hypothalamus increases gonadotropin-releasing hormone (GnRH) secretion. This increased GnRH stimulates the pituitary gland to release more luteinizing hormone and follicle stimulating hormone. The resulting increase in LH directly stimulates testicular function and endogenous testosterone production, while normal FSH supports continued sperm production.Pharmacokinetic profile of enclomiphene shows a half-life of about 10 hours, so daily dosing with rapid clearance. This is in contrast to zuclomiphene citrate which has a half-life of over 30 days and tends to accumulate in tissues and cause estrogen-agonist effects like mood swings and other side effects.

Comparative Research

Studies comparing enclomiphene to topical testosterone and testosterone gel showed notable differences in hormonal outcomes. Both treatments increased testosterone but enclomiphene compared to exogenous testosterone preserved LH and FSH and maintained sperm count instead of decreasing spermatogenesis. Traditional TRT suppressed gonadotropins and reduced sperm production.

Research comparing to clomiphene citrate showed that pure enclomiphene may have a better profile since it doesn’t have zuclomiphene’s weak estrogenic activity. Men with secondary hypogonadism treated with enclomiphene showed improvement in hormone levels without the accumulation concerns of the cis-isomer.

Storage and Safety

Proper storage ensures enclomiphene citrate remains chemically stable for research use:

• Temperature: Store at room temperature (15-30°C) in climate controlled environment
• Light Protection: Store in opaque or amber containers away from direct light
• Moisture Control: Store in dry environment with containers tightly sealed
• Handling: Use appropriate personal protective equipment including gloves and eye protection in laboratory settings
• Stability: Under proper storage conditions enclomiphene citrate is stable for about 2 years

Researchers should follow institutional safety protocols for handling research chemicals and dispose of materials according to local regulations. Solubility characteristics show enclomiphene citrate dissolves well in organic solvents like ethanol and methanol, with limited aqueous solubility.## Why Buy from Loti Labs

Loti Labs offers research grade enclomiphene citrate manufactured to high purity standards for in vitro research. Key benefits include:

• High Purity Verification: Each batch contains ≥98% enclomiphene with documented isomeric purity to confirm zuclomiphene free
• Comprehensive Documentation: Certificate of analysis included with every order, detailing HPLC purity results, identity confirmation and batch specific data
• Quality Manufacturing: Products made in USA/Canada facilities following GMP style protocols
• Competitive Pricing: Volume discounts for research institutions with ongoing study requirements
• Expert Support: Technical support from experts familiar with peptide and SERM research

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs are research chemical only. This designation allows the use of this chemical for in-vitro laboratory testing and experimentation only. Human or veterinary use is strictly forbidden. This product is not a drug, food or cosmetic and may not be misbranded, mislabeled or misused as such.

Enclomiphene is not FDA approved for any indication and is an investigational compound. Researchers must ensure their use complies with all applicable institutional and regulatory requirements for research chemicals.

Shipping Policy of Loti Labs

Loti Labs ships same day for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day. All shipments include secure packaging to maintain product integrity and tracking information for delivery status.

Satisfaction Guarantee

Loti Labs offers 30 day satisfaction guarantee on all products. Simply return any unopened products to us for full refund of the purchase price of the unused products. Our quality assurance team addresses any product quality concerns promptly.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs is third party tested using HPLC to ensure product purity and accuracy. Testing protocols verify chemical identity, quantify purity percentages and confirm zuclomiphene free—critical for research requiring pure trans-isomer enclomiphene citrate.

References

1. Wiehle RD, et al. Enclomiphene citrate increases testosterone and prevents oligospermia: a randomized phase II clinical trial comparing topical testosterone. Fertil Steril. 2014;102(3):720-727.

2. Kim ED, et al. Oral enclomiphene citrate increases testosterone and preserves sperm counts in obese hypogonadal men, not topical testosterone: restoration not replacement. BJU Int. 2016;117(4):677-685.
3. Kaminetsky J, et al. A 52-week study of dose-adjusted enclomiphene citrate in men with secondary hypogonadism. Clin Endocrinol. 2019;90(1):11-19.
4. FDA Advisory Committee Briefing Document: Enclomiphene citrate for secondary hypogonadism. 2016.
5. EMA Assessment Report: Enclomiphene citrate. 2018.